Mitochondrial Proteins as Molecular Targets For Glutathione-Based Drugs |Biomedgrid

Mitochondrion is one of the most important cell organelles which provide cells with energy, participate in cell turnover and activate endogenous mechanisms of cell-mediated immunity. Research into the structural and functional organization of mitochondria is extremely important and challenging for developing target pathways of drugs for various pathologies and aging. The purpose of this study is to investigate the effect of the V007 drug on the expression of mitochondrial biomarkers in myocardial and liver cells of elderly rats in vivo in order to find a possible mechanism of its target action. Molecular biological methods were used to study the expression of key mitochondrial proteins: Tom70, Tom20, VDAC, DRP1, Prohibitin, Parkin, PINK1 in myocardial and liver cells of elderly rats in the normal condition and with administration of the innovative V007 drug.