A Comparative Study on the Microstructural Change of Bony Endplate During Spinal Degeneration in Rats |Biomedgrid

Background and Objective: Bony endplate is a kind of sponge-like bone porous tissue, with a capillary network inside the heterogeneous foramina to provide the tissue structure foundation for the nutrition metabolism of the intervertebral disc. However, changes in bony endplate structure and foramina during spinal degeneration are poorly understood. This study aims to study the microstructural change of bony endplate and foramina during spinal degeneration in rats. Methods: Degeneration was made in the lumbar spine and coccygeal vertebra, respectively, of rats. Structural changes in bony endplate and foramina during spinal degeneration were analyzed by scanning electron microscopy and atomic force microscopy.