BIOMARKERS OF LEFT VENTRICLE REMODELING IN OVERWEIGHT PATIENTS WITH ESSENTIAL HYPERTENSION

The aim of our investigation was studying of cytokines activity in overweight patients with essential hypertension depending on peculiarities of left ventricle remodeling. Material and Methods. 152 patients were examined. Age 30- 80. The patients were sorted according to relative wall thickness. Standard clinical, laboratory and instrumental methods were used. Anthropometric measurements include: measurement of height (cm), weight (kg), calculation of body mass index and waist circumference. For carbohydrate metabolism evaluation the fasting glucose, glicated haemoglobin, fasting insulin "DRG InstrumentsGmbH" (Germany) were used. Insulin resistance was evaluated according ÍÎÌÀ (Homeostasis Model Assessment Insulin Resistance) calculation. Oncostatin M was investigated by ELISA, RayBio® Human Oncostatin M ELISA Kit, RayBiotech, Inc. For interleukin-6 measurement the ?ÍÒÅ?ËÅÉÊ?Í-6- ?ÔÀ-ÁÅÑÒ (Russia) kit was used. Ultrasound investigation was done using medical automatic diagnostic complex "Radmir" in Ì- and Â-regimens according to European and Ukrainian Associations of Echocardiography. Statistical calculation was done by Statistica 6.0. program pack. Results are represented as (M±m), where Ì - average mean, m - standard error. Significance of differences was discovered by Students' t-criterium. Correlations were calculated by Pierson (r) rank. Results and Discussion. The majority patients had moderate relative wall thickness. According to our investigation, left ventricular remodeling was developed according to anamnesis of the disease and systolic arterial pressure.Patients with increased relative wall thickness were characterized by significantly higher levels of oncostatin M and IL-6 comparing to ones with normal relative wall thickness. Correlation analysis showed positive relationship of oncostatin M, IL-6 and systolic arterial pressure, diastolic arterial pressure, anthropometric measurements and parameters of left ventricular remodeling in patients with essential hypertension. Conclusion. Results of our investigation showed involvement of oncostatin M, IL-6 in process of left ventricular remodeling in overweight patients with essential hypertension. Keywords: biomarkers, left ventricular remodeling, hypertension, excessive body weight