AN OPEN LABELLED CLINICAL TRIAL TO EVALUATE THE COMBINED EFFICACY OF MATRA BASTI, GODHUMA UPANAHA AND LAKSHADI GUGGULU IN THE MANAGEMENT OF JANU SANDHIGATA VATA VIS-A-VIS OSTEOARTHRITIS OF KNEE IN PERIMENOPAUSE WOMEN

Sandhigatavatais a disease in which Vata affects the joint causing pain and swelling, this is also characterized bypalpation which feels like bag filled with air and pain experienced during extension and flexion of joint.The disease janu Sandhigata vata is described asOsteoarthritis (OA)which manifests the abnormality of the synovial joints characterized by softening, splitting and fragmentation of articular cartilage not attributable to direct contact with inflammatory tissue.osteoarthritis tends to have a stronger association with women during perimenopause (Rajonivrutti). The prevalence rate of OA in perimenopause women is 31.6%. Perimenopause is menopausal transition phase to nonproductive stage in women. It includes somatic, phychological and uro-genital symptoms. The somatic symptoms make phase difficult to cope with routine life. In Ayurveda It can be understood as Rajonivrutti is JarakalajaSwabhavikaavastha during this phase Kshaya of Bala, Utsaha, Veerya leads to Vata Prakopa. Considering all these, the present study was undertaken to evaluate the combined efficacy of Matrabasti, GodhumaUpanahaandLakshadiGuggulu in the management of Janu Sandhigata Vata. Objective of the study: To evaluate the combined efficacy of Matrabasti, GodhumaUpanahaandLakshadiGuggulu in the management of Janu Sandhigata Vata vis-a-vis Osteoarthritis of knee in Perimenopause women. Methods: The data was collected on 0th day, on the day of completion of MatraBasti and Upanaha Karma and Shamanoushadhisi.e. on 0th, 9th day 31st day. Results: Matrabasti, GodhumaUpanaha and LakshadiGuggulushowed clinical improvement and statistically highly significant results in reduction of Pain, Swelling, Stiffness, Crepitus and WOMAC-Index for Osteoarthritis with p value 0.000. in the management of Janu Sandhigata Vata in perimenopause women.