Folic Acid as an Exploiter of Natural Endocytosis Pathways in Drug Delivery

The use of polymers modified with folic acid in drug delivery to treat many diseases has long captivated the attention of scientists. Given the distinctive characteristics of folic acid in the realms of food, pharmaceuticals, and chemicals, this review explores the methods employed in bonding folic acid to diverse polymers through the lens of organic synthesis. Furthermore, it examines the behavior of folic acid that has been conjugated to different polymers in drug delivery, along with the interaction between folic acid and folate acceptors. It is important to acknowledge that the articles employed in this review span the years 2002 to 2023.