Ultrasonic and Microwave Effects on the Benzamide/Sulfuryl Chloride Mediated Benzoylation of Benzene Derivatives under Vilsmeier-Haack Conditions
Journal: Chemical Methodologies (Vol.7, No. 9)Publication Date: 2023-09-01
Authors : Marri Venkateswarlu; Mukka Satish Kumar; Chinna Rajanna Kamatala; Purugula Venkanna; Pondichery Kuppuswamy Saiprakash;
Page : 650-658
Keywords : Ultrasonic and microwave irradiation; Benzamide/ SO2Cl2; Rate accelerations;
Abstract
Benzamide/ Sulfuryl Chloride (SO2Cl2) reagent has been developed as a Vilsmeier- Haack(VH) reagent for benzoylation of aromatic compounds by using the conventional and ultrasonic sonication (US), and microwave (MW) conditions. Benzoylation is much more competent and faster than the analogous VH ((Benzamide/ POCl3) or (Benzamide/ SOCl2)) reagents and afforded benzoyl derivatives in good yields. Reaction times are moderately less than those observed with [Benzamide/ POCl3] and (Benzamide/ SOCl2) reagents. Reaction times are far less in microwave assisted (MWAR) reactions than ultrasonically assisted (USAS) reactions , which in turn are less than the conventional method with a decreasing trend: MWAR (seconds)
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