A REVIEW ON SUSTAINED RELEASE MATRIX TABLET

In the present study Sustained release matrix tablet is formulated mainly by wet granulation or direct compression method .Sustained release drug delivery maintains the therapeutic concentration of drug in the bloodstream over a long period of time and thus improves patient compliance by reducing frequency of dosing, minimized fluctuations in drug levels, lowering the therapeutic index and improving treatment efficacy. Nowadays Matrix tablets as oral solid dosage form are most suitable for the sustained release drug delivery. In a matrix system a drug is homogeneously dispersed or dissolved within the hydrophilic or hydrophobic polymer like HPMC, PEG through various (diffusion, dissolution, ion exchange and pH dependent formulations) mechanism.