Study on Pharmic Effects of Anti-Inflammatory and Ease Pain of Arsenous Acid Injections |Biomedgrid

Objective: To explore anti-inflammatory and ease pain effects of Arsenous Acid (AA) injection. Methods: Measurement of mouse ear swelling caused by dimethylbenzene of rat posterior peri metatarsal swelling in Freund's complete adjuvant arthritis and of relative weight of rat spleen, thymus, adrenal gland, iliac lymph nodes to the whole body, to assess the anti-inflammatory effects of AA injection; observation of the sedative effects of AA injection on acetic acid-caused mouse writhing. Results: AA injection markedly inhibited acute inflammatory ear swelling following dimethylbenzene stimulation on mouse ear; therapeutic use of AA injection (4mg/kg) significantly decreased the swelling of adjuvant arthritis foot (right) and left (control) foots delayed allergic swelling on rat on the 5th and 8th treatment day; AA injection showed evident protective effects in adjuvant arthritis in scoring method, and markedly alleviated mouses writhing after acetic acid stimulation. Conclusion: Arsenous Acid (AA) injection has anti-inflammatory and ease pain effects.