STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES
Journal: International Journal of Advanced Research (Vol.12, No. 02)Publication Date: 2024-02-14
Authors : Aviraboina Siva Prasad; Talupula Venkateswara Rao;
Page : 528-532
Keywords : 2-Nitrotoluenes Green Chemistry Leimgruber-Batcho Substituted Indoles Economically Viable;
Abstract
Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions. Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach. Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles. Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.
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