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GENES OF THE BRAIN NEUROTRANSMITTER SYSTEMS DETERMINING THE HUMAN PSYCHOEMOTIONAL STATUS

Journal: Journal of the Grodno State Medical University (Vol.22, No. 1)

Publication Date:

Authors : ;

Page : 33-40

Keywords : psychoemotional status; genetic polymorphism; neurotransmitter systems;

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Abstract

Background. In recent decades, there has been a significant interest worldwide in the clarification of the genetic mechanisms of the human psychoemotional status. The identification of genetic markers associated with psychoemotional status expands the possibilities of considering individual characteristics in career guidance, as well as in choosing methods of individual psychotherapy. Purpose. To identify the most informative polymorphic variants of genes associated with the human psychoemotional status. Material and methods. Psychological and molecular genetic testing was conducted among representatives of two groups of the Belarusian population: a control group (518 people) and a group of patients with personality disorders and deviant behavior (534 people). The following psychological testing methods were used: PSS-10 and PSS-14 – Russian-language versions of the Perceived Stress Scale-10, HADS-T – a test that measures symptoms of anxiety, and HADS-D – a test that measures symptoms of depression. DNA isolated from buccal epithelial cells was used as biological material for molecular genetic research. Genomic DNA was isolated using an extraction kit from Primetech LLC (Belarus). DNA concentration was assessed using a Qubit fluorimeter (Invitrogen, USA), as well as a Promega GloMax® Explorer Multimode Microplate Reader (USA). Results. A total of 33 polymorphic variants of genes of the brain neurotransmitter systems have been studied. 8 polymorphic variants were found to have statistically significant different frequencies in the studied groups, and 3 ones to have frequencies that differ at the level of tendency. Conclusions. The results obtained made it possible to form a panel of the most informative polymorphic variants of genes of the brain neurotransmitter systems, which can be used to determine individual psycho-emotional characteristics.

Last modified: 2024-03-12 21:53:56