Exploring the role of autoantibodies in Iraqi females with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy that affects 5-10% of women during their reproductive age. Recent research suggests a potential link between autoantibodies and PCOS development. The current study aimed to investigate the relationship between autoantibodies and PCOS. One hundred and fifty female patients suffered from PCOS aged between 20 and 35 years participated in this study as matched with healthy control. The result showed a significantly higher concentrations of anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) autoantibodies in the patients compared to the healthy control group. Moreover, the concentrations of IgM and IgG for anti-cardiolipin (ACL) were significantly higher in the patients than in the control group. These increments in ACL antibodies in patients suggested a risk factor for PCOS. Conversely, no significant correlation was found in case of β-2 glycoprotein I (β2GPI) antibodies and lupus in patients. Serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) were significantly higher in patients. Procalcitonin (PCT) was also highly significant in patients compared to the controls. Lastly, the concentration of total IgG antibodies was significantly higher in patients than in controls. In conclusion, high concentrations of autoantibodies in patients suggest a risk factor and positive associations with PCOS in females.