Synthesis and Stability Constants of Transition Metal Complexes of Medicinal Ligands

Transition metal complexes comprise a central metal ion surrounded by coordinated organic ligands, together forming versatile scaffolds with diverse biochemical applications. The identity of the metal center and its oxidation state alongside the ligands within the coordination sphere enable extensive tuning of structural, electronic, and chemical properties. This has facilitated growing interest in transition metal complexes for therapeutic and diagnostic applications as metallodrugs or imaging agents. A key consideration underlying development efforts is quantifying metal complex stability. The stability constant reflects equilibrium binding affinity between the metal and ligands, with higher values indicating tighter interactions and more stable complexes. Multiple interdependent effects related to ligand denticity, geometry, electron configurations, solvation, entropy changes, kinetics, and reaction conditions all influence stability. Ayesha Meraj | Dr. Reshma Jawaria | Dr. Perwez Qureshi "Synthesis and Stability Constants of Transition Metal Complexes of Medicinal Ligands" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63455.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/63455/synthesis-and-stability-constants-of-transition-metal-complexes-of-medicinal-ligands/ayesha-meraj