Central Nervous System Disease Treatment Development Using Human Fetal-derived Neural Stem Cells/ Neural Progenitor Cells |Biomedgrid

Neural Stem Cells (NSCs) and Neural Progenitor Cells (NPCs) isolated from human fetuses are an attractive source for cell therapy for almost all Central Nervous System (CNS) diseases without the need for special treatments [1-3]. Human NSCs/NPCs are widely distributed in the fetal forebrain, Sub-Granular Zone (SGZ), Subventricular Zone (SVZ), and the dentate gyrus of the hippocampus in the adult brain [4,5]. NSCs/NPCs self-renew by proliferating in an undifferentiated state and can differentiate into neurons, oligodendrocytes, and astrocytes [6]. Damaged cells do not regenerate in mammals with CNS diseases, including humans. Transplanted NSCs/NPCs proliferate and continue to differentiate into neuronal and glial cells.