Dynamics of morphofunctional parameters in experimental pseudomonosis of rabbits

Among the most frequently reported diseases of rabbits, the main place is occupied by diseases of bacterial etiology, the pathogens of which are characterized by multidrug resistance. The aim of the study was to analyze the dynamics of morphometric indicators during experimental infection of rabbits with Pseudomonas aeruginosa bacteria. When assessing colonization resistance of organs, the following indicators were taken into account: colonization index, ratio of the number of microorganisms isolated from nasal cavity washes, contents of cecum of clinically healthy and sick animals. Significant changes in morphological parameters (p ≤ 0.05) were revealed during the isolation of P. aeruginosa from blood, lymph nodes, spleen, liver, and kidneys of sick rabbits. Overgrowth of isolates producing adhesive antigens, hemolysins, bacteriocins should be considered as prognostic markers of connective tissue dysplasia. The initiation, development, and outcome of microbial overgrowth syndrome are mediated by morphofunctional changes in compensatory mechanisms of mucociliary clearance system and colonization resistance.