Massive Progress of Green Synthesized Silver Nanoparticles in Cancer Application |Biomedgrid

Nanobiotechnology has become one of the hottest sections in nanoscience allowing the utilization of multiple nanoplatforms for a variety of biomedical technologies and applications. These nanoparticles play an effective role in solving several scientific dilemmas and in assisting in treating diverse diseases over the recent years due to their unique physicochemical features along with their higher delivery ability of cargoes into diseased targets [1]. Amongst these nanoparticles, silver nanoparticles (AgNPs), are metalbased nanoparticles possessing remarkable characterizations, for instance, good conductivity, comparatively lower toxicity, chemically structured stability, and potentially therapeutic option as antimicrobial, anticancer, or anti-inflammatory activity [2]. AgNPs are mainly synthesized by different biological, chemical, photochemical, electrochemical methods [3]. There are numerous biological principles of AgNPs synthesis, while the difference among them is due to the source of the biological route. Moreover, some microorganisms and plant extracts have been employed for biological AgNPs synthesis (AgNPs Biogenethesis) to ensure higher degree of AgNPs efficacy and safety. Interestingly, biogenic AgNPs have possessed a great impact as an antimicrobial candidate against gram-positive, gram-negative bacteria and several viruses such as herpes simplex virus, hepatitis B virus, and human immunodeficiency virus, thus this makes AgNPs have powerful capability to exert their cytotoxic activity for combating the diseases [4]. On the other hand, biogenic AgNPs have taken the researcher's and scientist's considerations either alone or in combination, for ameliorating the unfavorable toxicities results of conventional chemotherapies [5]. These serious side effects which are related to using chemotherapy include cardiovascular disturbances, wholebody fatigue, multidrug resistance, and high relapse rate.