Analysis of The Detection of Polymorphisms in The Elastic Fiber System Gene rs2018736 A456C Of the FBLN 5 Gene in Women with Post Hysterectomy Genital Prolapse |Biomedgrid

The article presents the results of molecular genetic studies of the rs2018736 A456C gene of the FBLN5 gene in women with posthysterectomy genital prolapse. 92 women aged 31 to 67 were examined. The results of the study showed that the C allele and hetero/homozygous genotypes of the rs2018736 A456C polymorphism of the FBLN 5 gene are significant markers of an increased risk of PHEGP in women of the Uzbek population (P<0.004). (χ2=27.30; p<0.0006; OR=10.81; 95%CI 2.35-49.68). The A allele and the functionally favorable A/A genotype are reliable protective markers for the development of pathology (χ2=30.84; p<0.001; OR=6.37; 95%CI 3.21 -12.63).