Chemical Profile and Anti-Metabolic Syndrome Potentials of Methanol Extract of Sida Acuta Leaves in Wistar Rats |Biomedgrid

This study investigated the possible ameliorative potentials of methanol extract of Sida acuta leaves (MESA) against high- fat diet (HFD) induced metabolic syndrome in rats. Forty (40) male albino rats were randomized into 4 groups of 10 animals each. Group 1 served as normal control and the rats were fed standard rat diet for 90 days. Rats in Group 2 were fed HFD for 90 days and served as negative control. Groups 3 and 4 rats were fed HFD for 90 days and administered 200 and 400mg/kg MESA concurrently for 90 days. The effects of treatment on some components of metabolic syndrome (hyperglycaemia, insulin resistance obesity and dyslipidaemia) were investigated through the measurement of body weight, fasting blood sugar (FBS), serum insulin level, total cholesterol (Tchol.), triacylglyceride (TAG), High density lipoprotein (HDL) and Low-density lipoprotein (LDL) concentrations. Results showed that administration of the extract at doses of 200 and 400mg/kg for 90 days significantly (p< 0.05) reduced body weight, FBS, insulin level, TAG and LDL as well as significantly (p< 0.05) increased serum levels of HDL. It was concluded that since, the methanol extract of Sida acuta leaves exerted beneficial effects on blood glucose, plasma insulin concentration, body weight, BMI and serum lipids of HFD-fed rats. It possesses significant anti-metabolic syndrome potentials.