Myocardial remodeling as an important mechanism in the development of Chronic Heart Failure |Biomedgrid

Heart failure (HF) is a leading cause of late morbidity and mortality after acute myocardial infarction worldwide. Nearly half of the patients with heart failure are associated with coronary heart disease. The treatment of chronic heart failure has changed from emphasis on improving symptoms and quality of life to focus on prevention and delay of myocardial remodeling, reducing mortality and readmission rate. Myocardial remodeling is an important mechanism in the development of chronic heart failure. Development of the HF phenotype in these patients arise from a complex, progressive, molecular and cellular transformation called “ventricular remodeling” first described by Tenant and Wiggers. Ventricular remodeling includes dilation of the ventricle, the formation of scar and geometrical charges in the overall left ventricle (LV) shape (i e, ellipsoid to more spherical). In this paper, according to the treatment guidelines and large-scale research results, the research progress of myocardial remodeling is summarized as follows.