A COMPARATIVE STUDY OF THE EFFICACY OF NANOCRYSTALLINE SILVER WITH COLLAGEN BASE CREAM AND 1% SILVER SULFADIAZINE (SSD) CREAM ON THE HEALING OF BURN WOUND

Background:The aim of burn management is to prevent hypovolemic shock ,infection ,septic shock, to promote early epithelialization as well as healing of wound . The present study aimed to compare the effects of Nano crystalline silver with collagen base cream and 1% silver sulfadiazine cream on the healing of burn wounds. Materials & Methods: A clinical prospective observational studyPatients with burn wounds were divided into two groups , one group was dressed with 1% silver sulfadiazine cream and the other group of patients was dressed with nano crystalline silver with collagen base cream. The wound dressing was changed everyday after washing the wound with normal saline. Wound parameters were assessed regularly , using clinical methods and photographs. The clinical data were statistically analyzed and results produced. Results: In this department study ,using silver sulphadiazine cream &nano crystalline silver with collagen base cream , enhanced epithelisation& granulation tissue following decreased slough was observed and the results were better with nano crystalline silver with collagen base cream because of early and increased appearance of granulation tissue in the wounds & this was also proved by statistical analysis.The mean hospital stay was less in patients who were undergoing dressing with nanocrystalline silver with collagen base cream. Conclusions: The effect of nanocrystalline silver with collagen base cream on the reduction of the healing time and necrotic tissue amount and increasing the granulation, epithelialization, and decreasing the necrotic tissue/slough was greater when compared to application of 1% SSD cream. Considering the above findings nanocrystalline silver with collagen base cream is more recommended to be used for burn wounds.