Future Challenges to Target Cancer Stem Cells
Journal: Enliven: Challenges in Cancer Detection and Therapy (Vol.1, No. 1)Publication Date: 2014-12-15
Authors : Pranela Rameshwar;
Page : 1-1
Keywords : Cancer hierarchy; Breast cancer cells in bone marrow; Targeting CSCs;
Abstract
The experimental information indicates that effective cancer treatment requires targeting of the tumor initiating cells. The initiating cells share molecular and functional properties with stem cells; hence their designation cancer stem cells (CSCs). The CSCs maintain tumor growth and are responsible for cancer resurgence. Also, there is evidence that the CSCs could be responsible for tumor dormancy and drug resistance. The functional and molecular similarities of CSCs and healthy stem cells pose challenges when considering the development of methods to target CSCs without harm to the endogenous stem cells. The review focuses on the potential challenges to target CSCs within the bone marrow niche.
Other Latest Articles
- Cancer Stem Cells (Csc's): Emerging Concept and Stratgey for Targeting Progression of Epithelial Ovarian Cancer
- Letter
- Cardiac Autonomic Neuropathy and Two Insulin Resistance Indices
- Inflammation and Oxidative Stress in Acute Coronary Syndromes: A Continuum from Plaque Vulnerability to Thrombus Formation
- Tissue Doppler Imaging in the Early Detection of Diastolic Dysfunction in Asymptomatic Diabetic Patients
Last modified: 2015-05-25 16:58:14