Epidemiology of Chronic Myeloid Leukemia in Tunisia |Biomedgrid

Chronic myeloid leukemia (CML) is a rare clonal myeloproliferatives disorder characterized by enhanced proliferative capacity and prolonged survival of hematpoietic stem cells.The pathogenesis of CML is driven by a bcr-abl fusion oncoprotein formed by a balanced translocation between chromosomes 9 and 22. Prevalence rate of CML has increased by use of tyrosine kinase inhibitors that transformed CML into a chronic disease. Reliable epidemiological information on CML in Low and Middle income countries is limited. Geographic and/or ethnic variation might contribute to the variability of incidence among registries. To retrospectively review characteristics of CML Tunisian patients, we followed up newly diagnosed chronic myeloid leukemia patients in Tunisia between January 2011 and December 2019.