Modeling the Encapsulation of Turmeric in Nanoemulsions

The interaction of turmeric powder with five surfactants (isopropyl oleate, diester of sucrose, polymethylene-α, ω-bis (N, N-dialkyl-N-deoxy-d-glucitolammonium iodides, bis [2-butyl (sodium bis-thioacetate) sodium dicarboxylate 1,10 decanediyl] ester, demecarium bromide) and obtaining nanoemulsions, has been investigated by spectroscopy, dynamic light scattering, optical microscopy and microbiological tests. The modeling encapsulation of turmeric powder in nanoemulsions was carried out taking into account the following parameters: the concentration and type of surfactants, the ratio between turmeric and surfactant, micellar critical concentration, speed and time of stirring, temperature, pH, average diameter of particles, zeta potential, conductivity. The known antibacterial and anti-inflammatory properties of turmeric can be improved by dispersing it in nanoemulsions resulting in better functional efficacy. The specific factors in designing nanoemulsion systems that affect the chemical stability of the encapsulated turmeric are discussed. In order to enhance turmeric effectiveness and improve bioavailability, surfactant assemblies as the colloidal carriers with desired properties have been largely used. The interaction takes place above the critical concentrations of the surfactants, when the encapsulation/ solubilization of turmeric in the micelles occurs. In our research we have elaborated a method for including turmeric in surfactants, following the preparation parameters modeling with the final aim of developing enhanced antibacterial properties.