Understanding The Role of Mitochondria in The Processes of Differentiation of Mesenchymal Stem/ Progenitor Cells and Male Germ Cells in Case of Male Infertility |Biomedgrid

Differentiation of derived from in vitro-incubated adult human mesenchymal stem cells (MSCs), isolated from bone marrow, cartilage and adipose tissue, respectively, by application of appropriate incubation conditions, to osteoclasts, was investigated and proved. The current results show the importance of the changes in the mitochondrial dynamics about the differentiation of male germ cells (spermatogonia) to mature and functional activity gametes (spermatozoa), as well as of the MSCs in direction osteoclasts and thus, of the receptor activator of tartrate-resistant acid phosphatase (TRAP). In this way, the current results were in agreement with the literature data and confirmed the key role of these organelles in the differentiation direction of stem/progenitor cells. Furthermore, a possibility for the development of new mitochondria-based strategies for the needs of regenerative medicine and assisted reproduction could be proposed.