Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Telmisartan in Combined Dosage Form

A simple, reproducible, economical, accurate, and precise UV spectrophotometric method for simultaneous estimation of Atorvastatin Calcium (ATC) and Telmisartan (TEL) in tablet dosage form has been developed. The absorption maxima at 246 nm and 273 nm were used for the estimation of Atorvastatin Calcium and Telmisartan respectively. A calibration curve was plotted over a degree range of 2-20 μg/ml for Atorvastatin Calcium and 1-6 μg/ml for Telmisartan respectively. Recovary was found at 90.14%for ATR and TEL 99.05 % using proposed UV spectrophotometric Telmisartan. The method was validated according to International Conference on Harmonization (ICH) guidelines with respect to linearity, recovery, precision, LOD, and LOQ. The validation study statistically significant as all the statistical parameters are within the acceptance range (%RSD < 2%). The developed method is simple, inexpensive, and accurate.