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Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia

Journal: Molecular Biology Research Communications (Vol.13, No. 3)

Publication Date:

Authors : ; ; ; ; ; ; ; ;

Page : 175-182

Keywords : FLT3; ITD; Acute myeloid leukemia; Prevalence; West of Algeria;

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Abstract

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 ligand gene (FLT3-ITD) represents an important factor in the prognosis of AML. The objective of this study was to determine for the first time the prevalence of FLT3-ITD mutation in west Algerian AML patients. A total of 160 AML patients were genotyped for FLT3-ITD mutation by using polymerase chain reaction. FLT3-ITD mutation was detected in 13% of patients. Mutation rates show no significant difference in the distribution of sex and age. A positive association was found between this mutation and a higher leukocyte and blast cells counts. We also found that the M3 and M5 subtype were the commonest in the FLT3 mutated group. This preliminary study provides first-time prevalence estimates for FLT3-ITD mutation in acute myeloid leukemia patients from the West region of Algeria.

Last modified: 2024-07-02 16:49:48