Efficacy of Capsaicin on Cell Adhesion and Invasion of Oral Pathogens

Streptococcus pyogenes, Streptococcus mutans, and Candida albicans are important human pathogens and their infections in the mouth, mouth, and throat are important. Prophylaxis against oral and respiratory tract infections is of great importance in terms of both reducing the use of antibiotics and lowering the infection frequency. This study investigated the antimicrobial activity of Capsaicin against S. mutans, C. albicans, and S. pyogenes. Non-cytotoxic concentration of Capsaicin was determined in the Vero cell line by the MTT method. Efficacy studies were performed within these determined non-cytotoxic concentrations. The efficacy of single and different combinations of these three biological components on cell adhesion and invasion. The non-toxic concentration of capsaicin on Vero cells was <1.35 µg/ml. Capsaicin exhibited significant antimicrobial activity against S. pyogenes, S. mutans, and C. albicans. Moreover, capsaicin was statistically significantly effective against host cell adhesion and invasion against S. mutans, S. pyogenes and C. albicans compared to the control group. The results showed that capsaicin is a highly potent antibacterial agent against S. pyogenes, and S. mutans, as well as an important prophylactic agent for fungal infections. As a result, we think that capsaicin is a useful molecule for the provision and maintenance of both respiratory diseases and oral health.