Green Preparation of Diclofenac Potassium via Electrospun Nanofibers Based on Synthetic Polymer

Electrospinning is used to prepare fine fibers mats from polyvinyl alcohol (PVA) solution that contains diclofenac potassium (DP) which is used in the treatment of local pain on the affected area to reduce the inflammation. The solution and process parameters (i.e. solution concentration, applied voltage current, flow rate, and needle-collector distance) affect the morphology of the fibers; which was studied using SEM to obtain fibers with diameter within the nano-size range. Generally, the average nanofibers diameter that obtained from SEM images are 1115 nm and 1864 nm for 10% PVA/DP and 15% PVA/DP, respectively, which indicate that, the diameter of nanofiber diameter increases with increasing the concentration of PVA at constant applied voltage current 30 Kv, flow rate of 0.5 mL/hour, and needle-collector distance 8 cm.