The Relationship between TLR2 SNP Polymorphism and IL10, IL6 Levels in Atopic Dermatitis Patients

Inflammatory diseases like atopic dermatitis have shown a correlation between changes in immune responses and variations in the TLR2 gene, with a specific focus on how TLR2 polymorphisms influence IL- 10 and IL-6 levels in individuals with AD. Fifty eight patients with atopic dermatitis and 32 healthy controls provided blood samples for analysis. IL-10 and IL-6 levels were measured using Elisa assay, and TLR2 gene variants were identified with Sanger sequencing. The results revealed that TLR2 polymorphisms, particular¬ly (T-6686-A), were not significantly associated with AD patients compared to healthy controls. There was a significant increase in the IL-6 and IL-10 levels between atopic dermatitis patients and healthy control. Otherwise, the result showed a significant increase in the IL-6 level and no significant increase in the IL- 10 level between AD patients' men and women. These results suggest a potential link between TLR2 genetic variations and altered IL-10 or IL-6 levels in AD patients, highlighting the influence of TLR2 polymorphisms on immune responses in this condition. Studying TLR2 polymorphisms' effect on cytokine profiles could of¬fer insights into AD pathogenesis and guide personalized immune-targeted therapies for affected individuals. The absence of significant differences in the distribution of genotypes among various allele variants may be due to the small size of the sample or the variant TLR2 (rs4696480). Individuals with AD often exhibit ele¬vated levels of IL-6 and IL-10, highlighting the complex immune dysfunction associated with this condition.