Cell Free Fetal DNA As Biomarker for Pregnancy Loss Disorders |Biomedgrid

Cell free fetal DNA (cff DNA) is apoptotic fetal DNA that is shed from placenta and flows in maternal blood. This can be used as an indicative biomarker to rule out pregnancy associated complications. The objective of this study is to investigate the correlation of the concentration of cff DNA with intrauterine deaths. The RHD gene (Rh blood group, D antigen) was used as fetal DNA marker for the confirmation of fetal DNA and GAPDH gene (Glyceraldehyde-3-phosphate dehydrogenase) was used as internal control. The control group comprises of 54 healthy singleton pregnant women without any history of pregnancy associated complications or fetal chromosomal abnormalities. The control group was confirmed by follow up for the delivery of normal baby.