CHANGES IN BLOOD BIOCHEMICAL PARAMETERS IN WISTAR RATS AFTER IMPLANTATION OF VASCULAR GRAFTS
Journal: Journal of the Grodno State Medical University (Vol.22, No. 3)Publication Date: 2024-07-30
Authors : H. A. Popel I. A. Maiseyenka A. A. Kopats I. P. Zhavaranak;
Page : 211-216
Keywords : biological vascular graft; bovine xenopericardium; synthetic vascular graft; Dacron; Wistar rats;
Abstract
Background. This article deals with the use of biological vascular grafts made from bovine xenopericardium as a plastic material for reconstructive operations on the great vessels, which is one of the most important topics in modern vascular surgery. Aim. To compare changes in blood biochemical parameters in Wistar rats after implantation of fragments of biological and synthetic vascular grafts. Material and methods. The experimental study was performed on male laboratory Wistar rats (n = 50). The animals were divided into two groups: group 1 included 25 animals with implantation of a Dacron vascular graft; group 2 was composed of 25 animals with implantation of a vascular graft made from bovine xenopericardium. Blood samples from the laboratory rats were collected on days 3, 7, 14, 21 and 30 after the operation. Plasma urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase levels were measured. Results. No clinically significant changes in concentrations of low molecular weight metabolites of nitrogen metabolism or liver enzymes activity, alkaline phosphatase and lactate dehydrogenase activity were observed after implantation of a biological vascular graft from bovine xenopericardium compared to the animals with implanted synthetic vascular graft. Conclusion. The use of a biological vascular graft made from bovine xenopericardium does not cause clinically significant changes in blood biochemical parameters in laboratory rats.
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