Plasma Polyunsaturated Fatty Acid Levels in Patients with Chronic Kidney Disease on Dialysis |Biomedgrid

Aim: Determination of plasma concentrations of some polyunsaturated fatty acids and plasma omega 3/omega 6 ratios in patients with chronic kidney disease (CKD) on dialysis. Methods: The study was conducted on 188 people, from 18 to 70 years old, including 64 CKD patients on dialysis (study group), 60 CKD patients with conservative treatment (disease control group) and 64 normal healthy people (healthy control group). The concentration of unsaturated fatty acids was measured by gas chromatography-mass spectrometry. Total cholesterol, triglycerides, HDL-C, LDL-C, Total protein, albumin, CRP, urea, glucose, creatinine in plasma were measured by photometric methods. Results: The plasma saturated fatty acids of the three groups were roughly equivalent. The omega 3 Arachidonic acid (AA), Eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA) decreased in the study group compared with the other groups (p<0.05), EPA levels and DHA of the disease control group was lower than that of the healthy control group (p<0.05), there was no difference in ALA concentration between these two groups (p>0.05). Omega 6 such as Linoleic acid (LA), Arachidonic acid (AA) decreased, the lowest in the group 1, the highest in the group 3 (p<0.05). The ratio of omega 3/omega 6 (ω3/ω6) and total polyunsaturated fatty acids/ω6 decreased in groups 1 and 2 compared with group 3 (p<0.05). The group of patients with dialysis time less than 60 months had higher plasma omega concentration than the group with dialysis time over 60 months (p<0.05). Conclusion: The concentration of ω3 and ω6 and the ratio of ω3/ω6 in CKD patients on dialysis decreased compared with the group of CKD patients on conservative treatment and the healthy control group. The longer the dialysis time, the lower the concentration of unsaturated fatty acids. This confirms that the supplementation of unsaturated fatty acids for patients with chronic kidney disease on dialysis is necessary.