REDUCTION BLOOD LOSS IN TKA: TRANEXAMIC ACID ARTHROPLASTY UNIT: ARMED FORCES HOSPITAL SOUTHERN REGION, KHAMIS MUSHAIT, KSA

Background:Total knee arthroplasty is the ideal surgical option for the management of severe pain in the arthritic knee.However, this surgery carries a high risk for blood loss due to the involvement of soft tissue and bone cuts in the knee region.Blood loss during Total Knee Replacement can lead toincreased morbidity, including longer stays in the hospital and delayed rehabilitation. Therefore, it is ideal to reduce the amount of bloodloss pre and post-operative. Tranexamic acidan anti-fibrinolytic agent has beenusedto achieve this goal with success. Aim:Our study is Cohort comparative study to compareefficacy of 1 Gram TXA with placebo group. Methods:This study was conducted at armed forces hospital southern region(AFHSR) on patients who performed primary total knee arthroplastyduring the period fromApril 2022 to December 2022 . The patients were simplerandomized into two groups those who received tranexamic acid and those who didnt. SPSS program version 23 was used to analyze the collected data a comparison was performed between the two groups. Results:The study included 50 patients who underwent total knee replacement Group one received tranexamic acid, and the Group Two didnt. The mean±SD of the total patients was 69.8 ±11.8 years, and regarding the two groups, there was no considerable difference between the two groups (P=0.2). There were significant differences between the two groups regarding gender (P=0.005) and dressing (P=0.002). There was no patient in the study who required a blood transfusion. Conclusion:TXA can be used for TKA patients to reduce blood loss postoperatively however, its impact on blood loss seems to be insignificant.