ACTIVITY TEST OF DIBUTYL TIN (IV) N-ETHYL BENZYLE DITHIOCARBAMATATE COMPOUNDS AGAINST Staphylococcus epidermidis AND Staphylococcus aureus
Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.9, No. 8)Publication Date: 2024-08-30
Authors : Mukhlis Sanuddin; Ellsa Lusiana Sihombing; Armini Hadriyati;
Page : 15-23
Keywords : Synthesis of Compounds; Dithiocarbamate; Antibacterial; Staphylococcus epidermidis; Staphylococcus aureus;
Abstract
The compound organotin (IV) complex divagate is widely used as an anticancer, antibacterial, and antifungal. This compound was successfully synthesized to find a picture of the structure and antibacterial activity against Staphylococcus epidermidis and Staphylococcus aureus bacteria. This compound was synthesized by the in situ method, namely by adding ethanol to ethyl benzyl + carbon disulfide + dibutyl tin (IV) dichloride, then identification was carried out using FTIR, IH NMR, and 13C NMR, then the antibacterial activity test was carried out using the disc diffusion method with concentrations of 60 ppm, 70 ppm, and 80 ppm and using NA (Nutrient Agar) media. The results of this study obtained 2.15 g of synthetic powder, then from the analysis of compound molecules using FTIR were obtained 1419.61 cm-1 (C-C), 1479.40 cm-1 (C=C), 2922.16 cm-1 (C-H), 2954.95 cm-1 (N-H), 960.55 cm-1 (C=S), 1176.58 cm-1 (C-N), 567.07 cm-1 (Sn-C), 360.69 cm-1 (Sn-S). ). The results of the analysis from the 13C NMR test were obtained 11.89-14.02 ppm (CH3 aliphatic), 26.57-48.63 ppm (CH2), 56.92 ppm (CN), 127.66-135.76 ppm (C6H5-aromatic), 201.75 ppm (CS2) and the results of antibacterial activity tests against Staphylococcus epidermidis and Staphylococcus aureus at concentrations of 60 ppm received the strong category.
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