Role of Vasoactive Intestinal Peptide in Mediating AntiInflammatory Response During Pregnancy: A Review |Biomedgrid

The role of Vasoactive Intestinal Peptide (VIP) as a potential regulatory neuropeptide in pregnancy was discussed. VIP is synthesized by trophoblast cells regulating its function and interaction with the major immune cell populations present in the pregnant uterus. An anti-inflammatory microenvironment is produced by VIP activity through modulating the functional profile of monocytes, macrophages, regulatory T cells and accelerated neutrophil apoptosis. The regulatory role of VIP on trophoblast-immune interaction is consistent for maintenance of immune homeostasis throughout pregnancy. These findings may provide ideas for the development of pharmacological agents targeting complications of pregnancy related to exacerbated inflammation.