Formulation and Evaluation of an Orodispersible Tablet of Empagliflozin Using a Natural Super Disintegrating Agent

Orodispersible Tablets (ODTs) are pharmacological formulations that are utilised to produce rapid therapeutic effects due to their improved compliance, bioavailability, ease of administration, and superior palatability. ODTs are highly preferable for administration in both paediatric and geriatric patients. The goal of this study was to combine natural disintegrants with the antihyperglycemic drug Empagliflozin to develop ODTs. The purpose of this research project was to use direct compression and a natural super-disintegrating agent to create an orodispersible tablet containing Empagliflozin. Isabgol, Crospovidone, and Sodium Starch Glycolate were the natural disintegrants that were utilised. Using 8 mm flat round punches, the Empagliflozin powder mixture was compacted into 200 mg weight tablets. Evaluation parameters for preformulation and postformulation, including bulk density, tapping density, hardness, weight variation, friability, and disintegration studies, were carried out. The study found that the targeted qualities of the orodispersible Empagliflozin tablets, including their immediate start of action, quick disintegration, enhanced patient compliance, and convenience, had been successfully formulated and tested.