‘Antiedemigeno Dog-Cat Slow Release’: A Potent In Vitro Inhibitor of LPS Activity |Biomedgrid

The present study wants to in vitro evaluate the effect of nutraceutical and chemical compounds on the adsorption, transport and permeability of endothelial cells. In particular, the research analyzed the ability of a specific nutraceutical product, ‘Antiedemigeno Dog-Cat slow release', to alleviate and repair endothelial damage using damaged cultured S-CADMEC cells (Human Dermal Microvascular Endothelial Cells) treated with lipopolysaccharide (LPS). The results obtained from this study showed that there is a dose-response reduction of vascular permeability after the administration of the ‘Antiedemigeno Dog-Cat slow release' respect to the cells treated with only LPS. In fact, a concentration of 0.312 mg/mL of ‘Antiedemigeno Dog-Cat slow release' promotes a 43% reduction in vascular permeability, while a concentration of 0.156 mg/mL induces a 30% reduction. These results are very important because encourage to treat endothelial damage and related increase in vascular permeability using natural components limiting the use of drugs with several side effects.