Development and Assessment of Sustained Release Matrix Tablet of Telmisartan

Development and Assessment of Sustained Release Matrix Tablet of Telmisartan the UV Visible spectra analysis of Telmisartan in methanol and water solvents discovered a consistent absorption peak at approximately 234 nm, indicating its characteristic absorbance wavelength. The FT IR spectrum highlighted functional groups such as hydroxyl, carbonyl, and aromatic rings present in Telmisartan, essential for identifying molecular characteristics. Formulation F8 emerged as the most promising option for sustained release matrix tablets of Telmisartan, demonstrating superior flow properties, compressibility, and tablet characteristics. Compatibility studies with various excipients indicated stable conditions at lower temperatures, but interaction challenges arose at elevated temperatures and humidity levels. Differential Scanning Calorimetry DSC analysis provided insights into the thermal behavior of Telmisartan and excipients, aiding in formulation optimization. Furthermore, formulation F8 exhibited prolonged floating time and sustained drug release in dissolution profiles, suggesting its suitability for once daily dosing regimens. Stability studies confirmed F8s robustness and reliability over a one month period, indicating its potential for clinical use. Further investigations may be required to assess long term stability under different environmental conditions. Sagar G Patil | Deepak S Maheshwari | Kalpeshkumar S Wagh | Kalpesh S More "Development and Assessment of Sustained Release Matrix Tablet of Telmisartan" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-4 , August 2024, URL: https://www.ijtsrd.com/papers/ijtsrd67146.pdf Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/67146/development-and-assessment-of-sustained-release-matrix-tablet-of-telmisartan/sagar-g-patil