Solubility Enhancement of Poorly Water Soluble Drugs A Review

Many drugs which have low solubility and high permeability poorly soluble and insoluble drug profile creates problems in pharmaceutical industry. The low dissolution rates and profile lower the bioavailability of drug when administered orally.Various techniques which review for enhancement of solubility of poorly water soluble drug techniques like solid dispersion, complexation, co solvency, hydrotropy, for improvement of poorly water soluble drug.The purpose of this review article is to describe the techniques of achievement of improved bioavailaibilty and absorption. Porosity and wettability improves and enhances the solubility and dissolution rate. The primary aim of this review is to improve the solubility and Bioavailability of drugs because of their low solubility and dissolution rate and leading to improving the poorly water soluble drugs. The techniques which leads to enhancing the poorly soluble drugs and desired activity is obtained.The solubility enhancement is most challenging aspect foe drug development pharmaceutically active ingredient with low solubility which creates problems in dru7g development and innovation. Swati S. Barve | Riyaj A. Mulla | Sakshi S. Sonje "Solubility Enhancement of Poorly Water Soluble Drugs: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-4 , August 2024, URL: https://www.ijtsrd.com/papers/ijtsrd67190.pdf Paper Url: https://www.ijtsrd.com/pharmacy/other/67190/solubility-enhancement-of-poorly-water-soluble-drugs-a-review/swati-s-barve