DETERMINATION OF IN VITRO ALPHA AMYLASE INHIBITORY AND ANTIGLYCATION STUDIES OF ROOT AND STEM EXTRACTS OF URENA SINUATA

Medicinal plants form the basic resource for the search of novel medicinal agents since ages. The search for new medicaments continues in preservance of human health due to various disease conditions. The plant Urena sinuata has been used in the treatment of diabetes in alternative systems of medicine. Diabetes is a chronic metabolic disorder of carbohydrates leading to many serious consequences. The remedial treatment suffers from lot of draw backs. In view of this, the present study underwent to investigate the anti-diabetic potential of root and stem extracts of the selected plant by in vitro methods - inhibition of alpha amylase and antiglycation. The hydroalcoholic extracts of the plant served appreciable role against diabetes forming evidence to its use in traditional systems of medicine. The results indicated that root hydroalcoholic extract showed equivalent activity in comparison to standard drug, acarbose in inhibiting alpha amylase at 500 µg/ml. Moreover, the root hydroalcoholic extract showed more antiglycation activity as compared to standard drug, rutin at 500 µg/ml. [Article No. 178] doi:10.21276/bpr.2023.13.1