PRECLINICAL EVALUATION OF POLYHERBAL AS AN ANTI- ALZHEIMERS, BY USING IN-VITRO ANTICHOLINESTERASE ENZYME MODEL
Journal: International Journal of Advanced Research (Vol.12, No. 09)Publication Date: 2024-09-15
Authors : Somvanshi S.R. Talware P.R. Gaikwad Y.S. Patil R.N.; Vyavhare P.V.;
Page : 1179-1191
Keywords : Neurodegenerative Disease Alzheimers Dementia Triterpenoids Flavonoids Acetylcholinesterase Mild Cognitive Impairment (MCI);
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Abstract
Background: Alzheimers disease is a neurodegenerative brain condition that causes mild cognitive impairment and memory loss, eventually leading to dementia. With developments in medicine, there are now more people in the world trying to treat a wider range of illnesses. It has been discovered that traditional herbal treatment works well with little or no adverse effects. Materials & Methods: There are certain chemical components in the polyherbal extract of liquorice, ginger, and hibiscus sabadariffa that have anti-Alzheimers properties. Results & Discussion: The polyherbal extract of liquorice, ginger, and hibiscus sabadariffa has been shown to have significant inhibition up to 44.02% in the group treated with it, which supports the extracts anti-Alzheimers activity. This was determined through a dose-dependent study and statistical comparison using Graph Pad Prism, version 10.2.2 by two-way ANOVA.
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