Correlation of renal function biomarkers in the first diagnostic approach to canine chronic kidney disease
Journal: REVISTA MVZ CÓRDOBA (Vol.28, No. 1)Publication Date: 2023-04-30
Authors : Alicia Pamela Pérez-Sánchez; Sofía Perini-Perera; Javier Del-Angel-Caraza; Israel Alejandro Quijano-Hernández;
Page : 1-11
Keywords : Chronic kidney disease; comorbidities; creatinine; canine; renal function biomarker; symmetrical dimethylarginine;
Abstract
Objective. To determine the correlation of kidney function biomarkers at the first evaluation in dogs with different risk factors identified for developing chronic kidney disease (CKD). Materials and methods. A descriptive, prospective study of cases and controls of 388 animals, divided into five groups: control group (CG), and four groups of potentially kidney-diseased dogs (pCKD) was carried out. Clinical history, physical examination, body condition score (BCS), complete blood count, biochemical profile with symmetrical dimethylarginine (SDMA), urinalysis, urine protein/creatinine ratio (UPC), and systemic blood pressure were analyzed. Non-parametric statistics were used, and data were expressed as medians and percentiles; for BCS, Xi2 was used. For biomarkers, Spearman's correlation was performed. Results. For SDMA and serum creatinine (sCr), a moderate correlation was observed for pCKD (r=0.69, p<0.001). Significant differences were observed in the variables age (p=0.002) and BCS (p<0.001) between the CG and the pCKD. Animals with mild azotemia (sCr 125–250 mmol/L) and/or with an SDMA value of 18–35 mg/dL, with or without proteinuria, had a greater probability of presenting an increase in SDMA when the BCS was below 5/9 (OR=3.55, p=0.005). Conclusions. SDMA is a useful complementary biomarker in pre-azotemic stages and advanced stages where there is cachexia and sarcopenia. Biomarkers must be evaluated together to have a complete perspective of renal function in animals with risk factors for developing CKD.
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