Mechanisms of VSMC Proliferation, Migration, and Phenotypic Transformation in Homocysteine-Induced Atherosclerosis: A Review |Biomedgrid

Evidence-based medical evidence has shown that homocysteine (Hcy) is an independent risk factor for atherosclerosis (As). If the pathogenesis of Hcy induction As can be elucidated, it will provide an important theoretical basis for the prevention and clinical treatment of As. Vascular smooth muscle cells (VSMC) are the main components of the vascular media, and the proliferation, migration, and phenotypic transformation of VSMC play an important role in the pathogenesis of Hcy induced As. This paper reviews the mechanisms related to the proliferation, migration, and phenotypic transformation of VSMC during Hcy induction of As.