INNOVATIVE MICROBIAL-BASED THERAPIES FOR POST-TRAUMATIC STRESS DISORDER

Aim. To investigate and systematize the literature data regarding the potential of novel biopreparations based on microorganisms as an innovative approach to the treatment of post-traumatic stress disorder (PTSD) through their impact on the microbiome and nervous system. Material and Methods. Structural-logical analysis and bibliosemantic analysis were used in this study. The research materials comprised general scientific works and international health care protocols in Ukraine. The search for articles and other scientific papers published in English and Ukrainian was conducted online using electronic databases such as Web of Science, Scopus, PubMed, and Google Scholar. Results. The relationship between microorganisms and the central nervous system through the so-called “enteric-cerebral axis” has been analyzed and systematized, revealing new opportunities for treating mental disorders, including PTSD. Studies indicate that the gut microbiome plays a crucial role in regulating the gut-brain axis, influencing the neuroendocrine system, immune response, and behavioral outcomes. Conclusions. The use of probiotics and prebiotics has demonstrated a positive effect in reducing symptoms of anxiety and depression, which are critical components of PTSD. However, further clinical studies are required to confirm the efficacy and safety of these biological treatments in the management of PTSD.