THERAPEUTIC FAILURE OF ANTIBIOTICS ININTENSIVE CARE UNIT: TOWARD BETTER RISK MANAGEMENT AND OPTIMIZED PATIENT CARE (PROSPECTIVE DESCRIPTIVE AND ANALYTICAL STUDY OF 100 CASES)

Infections in intensive care represent a critical situation where failure of anti-infective therapy, closely linked to high mortality rates, demands rapid detection and appropriate management by intensivists. Early intervention to identify and address treatment failure is therefore essential.This study aimed to determine the incidence of therapeutic failure, identify associated risk factors, and evaluate its prognostic consequences. We conducted a prospective, descriptive, and analytical study over nine months in the medical ICU of CUH Ibn Rochd in Casablanca. All patients receiving antibiotics for suspected or confirmed infections were included, with regular microbiological follow-up.Out of 100 patients, 58 experienced therapeutic failure. The causes were definitively identified in 53.5% of cases, probable in 34.4%, and undetermined in 12.1%. Infectious causes accounted for 41.4%, while non-infectious causes represented 12.1%. Key risk factors included severity at admission, nosocomial infections, atypical pathogens, irregular antibiotic administration, and anemia.