FUNCTIONAL GENE POLYMORPHISM AS INDICATOR OF ENDOCRINE DISRUPTION AMONG OVARIAN CANCER PATIENTS

Introduction: Increasing evidence of hormonal disruption and incidence of female reproductive cancers has been reported in recent years. Various documents support the alteration of epigenetic mechanisms and cancer progression among females. Ovarian cancer is one of the more prevalent with high mortality cancer in females. Its 90% progression is due to exogenous materials. These environmental contaminants alter hormonal activity by disrupting the endocrine system.