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THE ROLE OF GUT MICROBIOTA IN GASTROESOPHAGEAL REFLUX DISEASE: A SYSTEMATIC REVIEW
Journal: International Journal of Advanced Research (Vol.12, No. 12)Publication Date: 2024-12-18
Authors : Muhammad Zain Ali Zulqarnain Saeed Fareeha Shams Muhammad Faisal Iqbal Zabian Tahir; Sarim Ali;
Page : 761-772
Keywords : Gastroesophageal Reflux Disease (GERD) Gut Microbiota Probiotics Dysbiosis Microbiome Systematic Review;
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Abstract
Background: Gastroesophageal reflux disease (GERD) is a common digestive disorder characterized by retrograde flow of stomach contents into esophagus, leading to symptoms like heartburn and chronic cough. Worldwide prevalence of GERD varies, with lifestyle factors contributing to rising incidence. Current research indicates that gut microbiota plays a significant role in GERD pathophysiology, particularly through microbial dysbiosis and its influence on inflammation and mucosal integrity.
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