CHRONIC NEUTROPENIA REVEALING HYPER IGM SYNDROME: A CASE REPORT
Journal: International Journal of Advanced Research (Vol.12, No. 12)Publication Date: 2024-12-18
Authors : E. Bahous R. Abilkassem A. Radi M. Kmari A. Hassani; A. Agadr;
Page : 912-915
Keywords : Hyper Igm Syndrome Clinical Neutropenia Recurrent Infections Therapy Immunoglobulin;
Abstract
Hyper IgM syndrome is a well-knownhereditaryimmunodeficiency, first describedin 1961. It iscaused by a defect in B lymphocytes, characterized by a normal or high serumlevel of IgM and a low or zerolevel of IgG, IgA, IgE resultingfrom a deficiency in isotype switching. Itsclinical manifestations are dominated by recurrent infections, especiallyrespiratory and digestive. The interest of this article is to illustrate a particular mode of revelation of hyper IgM syndromes through persistent chronicneutropenia in an infant.
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