A study of blood parameters in rabbits with otitis caused by Malassezia pachydermatis and the effect of Farnesol on recovery rates when added to the treatment regimen

Malassezia otitis is very common disease among animals. In previous years, successful, published work was carried out on modeling Malassezia otitis in rabbits using a Malassezia pachydermatis strain taken from dogs. We reproduced this experiment — we induced a clinical picture of the disease in order to try different treatment regimens on this model. The study involved 35 rabbits. The animals were divided into 7 groups of 5 rabbits each. Each group received one of the following drugs: Surolan; Otifri; Otoxolan; Surolan + Farnesol 200 μM/ml; Otifri + Farnesol 200 μM/ml; Otoxolan + Farnesol 200 μM/ml; control without treatment. All drugs were applied to the entire affected surface of the ear. The treatment was carried out once a day, the duration of treatment was 30 days. It was found that the use of drugs in combination with Farnesol in animals of the experimental group reduced the clinical signs of the disease; elimination of fungi in smears occurred more quickly; clinical parameters of rabbit blood improved.