The morphometric parameters of non-parenchymal liver cells of 6–12-months old dead children from HIV-mono-infected mothers
Journal: The Journal of V.N. Karazin Kharkiv National University, series "Medicine" (Vol.52, No. 52)Publication Date: 2025-02-28
Authors : S.I. Panov S.O. Sherstiuk R.V. Sydorenko T.I. Liadova C. Shlomi;
Page : 69-80
Keywords : HIV liver Kupffer cells hepatic stellate cells liver-associated lymphocytes;
Abstract
Background. HIV infection remains one of the most pressing global medico-social challenges, affecting all age and social groups, including newborns and infants born to HIV-infected mothers. Despite the considerable amount of research dedicated to adult HIV-infected populations, data on the morphofunctional changes in the liver of infants within the first year of life remain limited. Of particular interest is the study of non-parenchymal liver cells – Kupffer cells, hepatic stellate cells, dendritic cells, and liver-associated T-lymphocytes – which play a crucial role in maintaining hepatic immune homeostasis.
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