Efficacy of combined rectal cream “dilatil” (diltiazem/lidocaine/methyl-uracil) in pre-clinical study on a model of acute complicated anal fissure

Aim. To assess efficacy of a new rectal cream “Dilatil” (diltiazem/lidocaine/methyluracil) (D) in pre-clinical study on a model of acute complicated anal fissure (ACAF). Materials and Methods. Animal model of anal fissure, macroscopic assessment, enzyme-linked immunosorbent assay, statistical Student's and Wilcoxon's tests. Results. At the end of the study, in the D group, the severity of the pathological process was statistically lower than in the Control pathology (CP) and N groups. Levels of IL-6, IL-10, and TNFin the homogenate of anodermal tissue (HAT) in the D group were significantly lower compared to CP. The level of IL-6 was significantly lower in the D group compared to the N group. Conclusions. Better efficacy of D vs N was observed in a pre-clinical study, which was also confirmed by the level of IL-10 in HAT tissue at the end of the experiment.